Volume 26, No 3, Mar 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 3, March 2016: 273-274

RESEARCH HIGHLIGHTS

Arresting supporters: targeting neutrophils in metastasis

Swarnali Acharyya^1,2 and Joan Massague³

¹Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
²Herbert Irving Comprehensive Cancer Center, New York, NY 10065, USA
³Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Correspondence: Swarnali Acharyya, E-mail: sa3141@cumc.columbia.edu; Joan Massague,(j-massague@ski.mskcc.org)

It is becoming increasingly clear that leukocytes dynamically regulate cancer progression and metastasis, and among leukocytes, granulocytic cells abundantly accumulate in metastatic organs; however, their function in metastasis remains controversial. In a recent report in Nature, Wculek and Malanchi clarify the role of mature neutrophils as mediators of metastatic initiation and provide a targeted approach to prevent the pro-metastatic activity of neutrophils in breast cancer models.

10.1038/cr.2016.17

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