Volume 26, No 4, Apr 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 4, April 2016: 391-392

RESEARCH HIGHLIGHTS

Mex3B, a coreceptor to present dsRNA to TLR3

Shu Zhu¹, Geng Wang¹, Xuqiu Lei¹ and Richard A Flavell^1,2

¹Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
²Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA Correspondence: Richard A Flavell,(richard.flavell@yale.edu)

Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in the endosomes and promotes dsRNA binding and proteolytic processing of TLR3, suggesting that Mex3B acts as a coreceptor of TLR3 in response to dsRNA.

10.1038/cr.2016.29

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