Volume 26, No 4, Apr 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 4, April 2016: 423-440   |  Open Access

REVIEWS

E2 enzymes: more than just middle men

Mikaela D Stewart^1,*, Tobias Ritterhoff^1,*, Rachel E Klevit¹ and Peter S Brzovic¹

¹Department of Biochemistry, University of Washington, Seattle, WA 98102 USA Correspondence: Rachel E Klevit,(klevit@u.washington.edu)

Ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes responsible for the attachment of ubiquitin (Ub) to cellular proteins. Humans have ~40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g., SUMO and NEDD8). Although the majority of E2s are only twice the size of Ub, this remarkable family of enzymes performs a variety of functional roles. In this review, we summarize common functional and structural features that define unifying themes among E2s and highlight emerging concepts in the mechanism and regulation of E2s.

10.1038/cr.2016.35

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