Volume 26, No 4, Apr 2016
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 26 Issue 4, April 2016: 423-440 | Open Access
REVIEWS
E2 enzymes: more than just middle men
Mikaela D Stewart1,*, Tobias Ritterhoff1,*, Rachel E Klevit1 and Peter S Brzovic1
1Department of Biochemistry, University of Washington, Seattle, WA 98102 USA
Correspondence: Rachel E Klevit,(klevit@u.washington.edu)
Ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes responsible for the attachment of ubiquitin (Ub) to cellular proteins. Humans have ~40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g., SUMO and NEDD8). Although the majority of E2s are only twice the size of Ub, this remarkable family of enzymes performs a variety of functional roles. In this review, we summarize common functional and structural features that define unifying themes among E2s and highlight emerging concepts in the mechanism and regulation of E2s.
10.1038/cr.2016.35
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