Volume 26, No 5, May 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 5, May 2016: 511-512

RESEARCH HIGHLIGHTS

Drosha and Dicer: Slicers cut from the same cloth

Sisi Li¹ and Dinshaw J Patel^1,2

¹Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong 518055, China
²Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Correspondence: Dinshaw J Patel,(pateld@mskcc.org)

DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between components of the Microprocessor and insights into its 'ruler'-based cleavage activity and function.

10.1038/cr.2016.19

FULL TEXT | PDF

Browse 1758