Volume 26, No 6, Jun 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 6, June 2016: 639-640

RESEARCH HIGHLIGHTS

MYC — a thorn in the side of cancer immunity

Stefani Spranger¹, Thomas F Gajewski^1,2 and Justin Kline²

¹Department of Pathology, University of Chicago, Chicago, IL 60637, USA
²Department of Medicine, University of Chicago, Chicago, IL 60637, USA Correspondence: homas F Gajewski, Tel: +1-773-702-4601; Fax: +1-773-702-3163(tgajewsk@medicine.bsd.uchicago.edu)

For decades, MYC has been known for its role in regulating cancer cell proliferation and survival. In a recent paper published in Science, Casey et al. have uncovered a new function for MYC in promoting immune evasion by directly regulating expression of programmed death-ligand 1 (PD-L1) and CD47 on cancer cells.

10.1038/cr.2016.50

FULL TEXT | PDF

Browse 1717