Volume 26, No 6, Jun 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 6, June 2016: 643-644

RESEARCH HIGHLIGHTS

Electrophysiologist shows a cation channel function of MLKL

Yingying Zhang¹ and Jiahuai Han¹

¹State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China Correspondence: Jiahuai Han,(jhan@xmu.edu.cn)

Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel, none-selective pore, or simply by disrupting plasma membrane is unclear. In a paper published in recent issue of Cell Research, Xia et al. showed that MLKL functions as a novel class of cation channel.

10.1038/cr.2016.64

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