Volume 26, No 7, Jul 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 7, July 2016: 751-752

RESEARCH HIGHLIGHTS

Prevention of breast cancer by RANKL/RANK blockade

Lorenzo Galluzzi^1,2,3,4,5, Aitziber Buqué^1,2,3,4,5 and Guido Kroemer^{2,3,4,5,6,7,8}

¹Gustave Roussy Cancer Campus, Villejuif, France
²INSERM, U1138, Paris, France
³Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
⁴Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France
⁵Université Pierre et Marie Curie/Paris VI, Paris, France
⁶Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France
⁷Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
⁸Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden Correspondence: Guido Kroemer, E-mail: kroemer@orange.fr; Lorenzo Galluzzi,(deadoc@vodafone.it)

Robust genetic evidence in mice and humans indicates that RANK signaling plays a major role in mammary carcinogenesis driven by BRCA1/BRCA2 mutations. These findings may inaugurate a new era of breast cancer prevention, changing the life of millions of women worldwide.

10.1038/cr.2016.79

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