Volume 26, No 7, Jul 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 7, July 2016: 757-758

RESEARCH HIGHLIGHTS

Coping with the metabolic stress of leaving home

Jonathan L Coloff¹ and Joan S Brugge¹

¹Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA Correspondence: Joan S Brugge, Tel: +1 617 432 3974; Fax: +1 617 432 3969 (joan_brugge@hms.harvard.edu)

Detachment from extracellular matrix causes metabolic defects that transformed cells must overcome in order to survive and proliferate outside of their normal niche. A recent report from Jiang et al. published in Nature describes how cancer cells grown in suspension utilize reductive carboxylation of glutamine to transfer reducing power from the cytosol to mitochondria to detoxify reactive oxygen species and promote anchorage-independent growth and survival.

10.1038/cr.2016.61

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