Volume 26, No 8, Aug 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 8, August 2016: 865-866

RESEARCH HIGHLIGHTS

LAP: the protector against autoimmunity

Urmi Bandyopadhyay¹ and Michael Overholtzer¹

¹Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Correspondence: Michael Overholtzer,(overhom1@mskcc.org)

The autophagy-related process LC3-Associated Phagocytosis, or LAP, is known to control the degradation of engulfed cells and microorganisms. Now Martinez et al. discover that LAP controls immune responses to dying cells and its inhibition leads to development of Systemic Lupus Erythematosus-like disease.

10.1038/cr.2016.70

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