Volume 26, No 8, Aug 2016
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 26 Issue 8, August 2016: 867-868
RESEARCH HIGHLIGHTS
Microenvironmental InterFereNce of metabolism regulates chemosensitivity
Leila Akkari1,2 and Johanna A Joyce1,2
1Ludwig Institute for Cancer Research, Lausanne, Switzerland
2Department of Oncology, University of Lausanne, Lausanne, Switzerland
Correspondence: Johanna A Joyce(johanna@joycelab.org)
The tumor microenvironment is recognized as a critical regulator of cancer progression, and multiple roles are also emerging for the microenvironment in modulating response to therapeutic intervention. A recent study by Wang and colleagues identified IFN-γ as a central effector of CD8+ T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells.
10.1038/cr.2016.82
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