Volume 26, No 8, Aug 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 8, August 2016: 869-885   |  Open Access

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The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

Ido Livneh^1,*, Victoria Cohen-Kaplan^1,*, Chen Cohen-Rosenzweig^1,*, Noa Avni^1,* and Aaron Ciechanover¹

¹Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel Correspondence: Aaron Ciechanover, Tel: +972-4-829-5427 Fax: +972-4-852-1193(aaroncie@technion.ac.il)

The 26S proteasome is a large, ~2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

10.1038/cr.2016.86

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