Volume 26, No 9, Sep 2016
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 26 Issue 9, September 2016: 971-972
RESEARCH HIGHLIGHTS
Restoring stem cells — all you need is NAD+
Lindsay E Wu1 and David A Sinclair1,2
1School of Medical Sciences, UNSW Australia, Sydney 2052, Australia
2Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Correspondence: David A Sinclair,(david.sinclair@unsw.edu.au)
The loss of stem cells, through cell dysfunction or senescence, is thought to contribute to biological aging. Recently, Hongbo Zhang and colleagues have shown that activation of the mitochondrial unfolded protein response, a retrograde stress response, through administration with an NAD+-raising compound, can rejuvenate stem cells and extend lifespan in mice.
10.1038/cr.2016.80
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