Volume 26, No 10, Oct 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 10, October 2016: 1073-1074

RESEARCH HIGHLIGHTS

How to open a Ryanodine Receptor

Filip Van Petegem¹

¹University of British Columbia, Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, V6T 1Z3 Vancouver, BC, Canada Correspondence: Filip Van Petegem,(filip.vanpetegem@gmail.com)

Ryanodine Receptors are large ion channels responsible for the release of Ca2+ from the Endoplasmic and Sarcoplasmic Reticulum, a prerequisite for muscle contraction. Recent cryo-electron microscopy data have allowed a direct visualization of allosteric motions within these membrane protein giants.

10.1038/cr.2016.106

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