Volume 26, No 10, Oct 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 10, October 2016: 1075-1076

RESEARCH HIGHLIGHTS

Ever HRD a ubiquitin-gated channel?

Ting Zhang¹ and Yihong Ye¹

¹Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA Correspondence: Yihong Ye, Tel: +1-301-5940845; Fax: +1-301-4960201(yihongy@mail.nih.gov)

Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membrane-bound ubiquitin ligase complexes. Baldridge and Rapoport now reconstitute a key step of retrotranslocation, demonstrating a protein conduit gated by ubiquitination.

10.1038/cr.2016.92

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