Volume 26, No 11, Nov 2016
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 26 Issue 11, November 2016: 1174-1175
RESEARCH HIGHLIGHTS
Warm feelings for TRPM2
Thomas Voets1
1Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, University of Leuven, Belgium
Correspondence: Thomas Voets,(thomas.voets@kuleuven.be)
Temperature directly impacts the function of biological macromolecules and every (bio)chemical reaction. To ensure that the body functions at a metabolically favorable temperature, mammals and other endotherms exhibit powerful thermoregulatory processes that maintain the body core temperature (Tcore) within a narrow temperature band1. In healthy humans, Tcore is typically maintained between 36.5 and 37.5 °C. Deviations from normothermia of only a few degrees, for instance due to disease, drug abuse or extreme environmental conditions, can have dangerous and even fatal consequences; temperatures > 40 °C or < 32 °C represent an acute medical urgency.
10.1038/cr.2016.121
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