Volume 26, No 11, Nov 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 11, November 2016: 1176-1177

RESEARCH HIGHLIGHTS

OTULIN deficiency causes auto-inflammatory syndrome

Berthe Katrine Fiil¹ and Mads Gyrd-Hansen¹

¹Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK Correspondence: Mads Gyrd-Hansen, Tel: +44 (0)1865 617508(mads.gyrd-hansen@ludwig.ox.ac.uk)

Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.

10.1038/cr.2016.113

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