Volume 26, No 11, Nov 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 11, November 2016: 1180-1181

RESEARCH HIGHLIGHTS

Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show

Rosalind F Roberts¹ and Edward A Fon¹

¹McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada Correspondence: Edward A Fon,(ted.fon@mcgill.ca)

In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.

10.1038/cr.2016.104

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