Volume 26, No 12, Dec 2016
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 26 Issue 12, December 2016: 1265-1266
RESEARCH HIGHLIGHTS
The mitokine quest(ion)
Pan Deng1,2 and Cole M Haynes1,2
1University of Massachusetts Medical School, Department of Molecular, Cell and Cancer Biology, Lazare Medical Research Building, Worcester, MA 01605, USA
2Weill Cornell Medical College, BCMB Allied Program, New York, NY 10065, USA
Correspondence: Cole M Haynes,(cole.haynes@umassmed.edu)
Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPRmt), which is regulated by mitochondrial-to-nuclear communication; and UPRmt activation can also be transmitted between different cell types suggesting a role in tissue coordination. Shao and colleagues now identify a neuronal circuit and a secreted neuropeptide required for cell non-autonomous UPRmt regulation.
10.1038/cr.2016.138
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