Volume 26, No 12, Dec 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 12, December 2016: 1267-1268

RESEARCH HIGHLIGHTS

Inhibiting macrophage PI3Kγ to enhance immunotherapy

Wei Zheng¹ and Jeffrey W Pollard^1,2

¹Department of Developmental and Molecular Biology, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA
²MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK Correspondence: Jeffrey W Pollard,(Jeff.Pollard@ed.ac.uk)

A recent paper published in Nature reports that the immunosuppressive activity of tumor-associated macrophages is regulated via PI3Kγ signaling. Small-molecule inhibitors targeting PI3Kγ stimulate T cell activity against tumor alone and add additional effects for clinically proven PD1 immunotherapy.

10.1038/cr.2016.132

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