Volume 26, No 12, Dec 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 12, December 2016: 1269-1270

RESEARCH HIGHLIGHTS

Codon optimality and mRNA decay

Yuriko Harigaya^1,2 and Roy Parker^1,2

¹Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA
²Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA Correspondence: Roy Parker, E-mail: roy.parker@colorado.edu

mRNA decay is a critical step in the gene expression process, and the decay rates of individual mRNAs can vary over two orders of magnitude. In eukaryotes, bulk mRNA decay is initiated by deadenylation1, which allows decapping and 5′ to 3′ degradation but can also lead to 3′ to 5′ degradation1.

10.1038/cr.2016.127

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