Volume 26, No 12, Dec 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 12, December 2016: 1345-1348

LETTERS TO THE EDITOR

Mapping of long-range chromatin interactions by proximity ligation-assisted ChIP-seq

Rongxin Fang^1,2,*, Miao Yu^1,*, Guoqiang Li¹, Sora Chee¹, Tristin Liu¹, Anthony D Schmitt^1,3 and Bing Ren^1,4

¹Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA
²Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA
³Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA
⁴Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA Correspondence: Bing Ren,(biren@ucsd.edu)

Formation of long-range chromatin loops is a crucial step in transcriptional activation of target genes by distal enhancers1,2. Mapping such structural features can help define target genes for enhancers and annotate non-coding sequence variants linked to human diseases1,2,3. Study of the higher-order chromatin organization has been facilitated by the development of chromosome conformation capture (3C)-based technologies4,5. Among the commonly used high-throughput 3C approaches are Hi-C6 and chromatin interaction analysis by paired-end tag sequencing (ChIA-PET)7.

10.1038/cr.2016.137

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