Volume 27, No 1, Jan 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 1, January 2017: 5-6

Research Highlight

Macroautophagy without LC3 conjugation?

Maurizio Renna¹ and David C Rubinsztein¹

¹Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2XY, UK Correspondence: David C Rubinsztein, E-mail: dcr1000@hermes.cam.ac.uk

A recent study makes the surprising observation that autophagosomes can still form in the absence of the core conjugation machinery. Furthermore, while such autophagosomes can fuse with lysosomes, their degradation is delayed, and this is associated with delayed destruction of the inner autophagosomal double membrane, highlighting a new role for proteins thought to act exclusively in the formation of autophagosomes in late stages of the autophagic itinerary within autolysosomes.

10.1038/cr.2016.143

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