Volume 27, No 1, Jan 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 1, January 2017: 7-8

RESEARCH HIGHLIGHTS

Hitting the right button: MAVS-mediated defense against HAV infection

Percy A Knolle¹

¹Institute of Molecular Immunology and Experimental Oncology Technische Universität München, Germany Correspondence: Percy A Knolle,(percy.knolle@tum.de)

Studying the immune response against infection with hepatitis viruses is hampered by the lack of suitable preclinical model systems. A recent publication in Science identifies the cytosolic adapter molecule MAVS as being responsible for species restriction of infection with hepatitis A virus as well as linking cytosolic immune sensing in infected hepatocytes with innate effector functions and protective adaptive immunity.

10.1038/cr.2016.139

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