Volume 27, No 2, Feb 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 2, February 2017: 294-297

LETTERS TO THE EDITOR

Heritable expansion of the genetic code in mouse and zebrafish

Yuting Chen, Ji Ma, Wenqing Lu, Meilin Tian, Marion Thauvin, Chonggang Yuan, Michel Volovitch, Qian Wang, Jeff Holst, Mingyao Liu, Sophie Vriz, Shixin Ye, Lei Wang and Dali Li

Correspondence:

The genetic code can be expanded to encode unnatural amino acids (Uaas) by introducing an orthogonal tRNA/aminoacyl-tRNA synthetase (aaRS) pair to decode a stop codon. Initially developed in Escherichia coli1, this strategy has been proven generally applicable in eukaryotic cells2 and in generating transgenic invertebrates capable of Uaa incorporation, including Caenorhabditis elegans3 and Drosophila melanogaster4.

10.1038/cr.2016.145

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