Volume 27, No 3, Mar 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 3, March 2017: 313-314

RESEARCH HIGHLIGHTS

New CRISPR-Cas systems discovered

Hui Yang¹ and Dinshaw J Patel¹

¹Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA Correspondence: Hui Yang, E-mail: yangh3@mskcc.org; Dinshaw J Patel, Tel: +1-212-639-7207; Fax: +1-212-715-3066(pateld@mskcc.org)

In bacteria and archaea, CRISPR-Cas adaptive immune systems utilize RNA-guided endonucleases to defend against invasion by foreign nucleic acids of bacteriophage, virus and plasmid origin. In a recent paper published in Nature, Burstein et al. identified the first Cas9 protein in uncultivated archaea and two novel CRISPR-CasX and CRISPR-CasY systems in uncultivated bacteria by capitalizing on analysis of terabase-scale metagenomic datasets from natural uncultivated organisms.

10.1038/cr.2017.21

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