Volume 27, No 3, Mar 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 3, March 2017: 448-451

LETTERS TO THE EDITOR

The glial actin cytoskeleton regulates neuronal ciliogenesis

Hao Zhu¹, Lianwan Chen², Yihong Yang¹, Zhiwen Zhu¹, Xianliang Zhang¹, Wei Li¹, Long Miao², Yan Zhang¹ and Guangshuo Ou¹

¹Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
²Institute of Biophysics, Chinese Academy of Sciences, Beijing 100081, China Correspondence: Guangshuo Ou, E-mail: guangshuoou@tsinghua.edu.cn; Yan Zhang,(zhangyan1011@gmail.com)

Cilia are remarkable microtubule (MT)-based organelles that are essential for cell motility, sensory perception and signal transduction1. Ciliary defects have been implicated in various human diseases1. Although the rod-shaped cilium morphology and the axonemal structure characterized by nine-doublet MTs were described decades ago2,3, the molecular regulations of cilium morphology and axonemal structure are still poorly defined. The formation and maintenance of cilia require bidirectional intraflagellar transport (IFT) that is powered by MT-based kinesin-2 and IFT-dynein motor proteins1,4.

10.1038/cr.2016.131

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