Volume 27, No 4, Apr 2017
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 27 Issue 4, April 2017: 453-454
RESEARCH HIGHLIGHTS
T(ell)TALE signs of aging
Reshma Taneja1 and Brian K Kennedy1,2,3
1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
2Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
3Buck Institute for Research on Aging, Novato, CA 94945, USA
Correspondence: Brian K Kennedy,(bkennedy@buckinstitute.org)
Transcriptional activator-like effectors (TALEs) have emerged as powerful tools for genome editing. A recent study published by Cell Research reports that fusion of thioredoxin to TALEs unlocks their full potential in live-cell imaging to accurately analyze genome instability, telomere attrition and epigenetic alterations that are hallmarks of aging.
10.1038/cr.2017.33
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