Volume 27, No 4, Apr 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 4, April 2017: 455-456

RESEARCH HIGHLIGHTS

Both sides of the same coin: Rac1 splicing regulating by EGF signaling

Xiang-Dong Fu¹

¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA Correspondence: Xiang-Dong Fu,(xdfu@ucsd.edu)

EGF, a well-studied mitogen for cancer cells, is revealed to induce an E3 ubiquitin ligase adaptor SPSB1, which recruits the Elongin B/C-Collin complex to trigger ubiquitylation of the negative splicing regulator hnRNP A1. This event is synergized with EGF-activated SR proteins to alter alternative splicing of a key small GTPase Rac1 to enhance cell migration, highlighting converging EGF signals on both negative and positive splicing regulators to jointly promote a key cancer pathway.

10.1038/cr.2017.19

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