Volume 27, No 4, Apr 2017
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 27 Issue 4, April 2017: 459-460
RESEARCH HIGHLIGHTS
Cancer: a new role for non-canonical Hippo signaling
Jonathan Cooper1 and Filippo G Giancotti2
1Research and Early Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA
2Department of Cancer Biology and David H Koch Center for Applied Research of Genitourinary Cancers, UT MD Anderson Cancer Center, Houston, TX 77230, USA
Correspondence: Jonathan Cooper, E-mail: cooper.jonathan@gene.com; Filippo G Giancotti,(FGGiancotti@MDAnderson.org)
The molecular mechanisms governing self-renewal and differentiation of the mammary epithelium are incompletely defined; a better understanding of the events implicated in the specification and expansion of luminal progenitors is of particular importance as many breast cancers originate from their transformation. Britschgi et al. found that, in addition to phosphorylating and inactivating YAP, LATS functions as a scaffold to facilitate estrogen receptor-α ubiquitylation by the E3 ligase CRL4DCAF1 and consequently suppresses luminal progenitor specification and expansion.
10.1038/cr.2017.27
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