Volume 27, No 4, Apr 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 4, April 2017: 586-589   |  Open Access

LETTERS TO THE EDITOR

Simultaneous enhancement of cellular and humoral immunity by the high salt formulation of Al(OH)3 adjuvant

Min Luo^1,*, Bin Shao^1,*, Jia-yun Yu^1,*, Ting Liu¹, Xiao Liang¹, Lian Lu¹, Ting-hong Ye¹, Zhi-yao He¹, Heng-yi Xiao¹ and Xia-wei Wei¹

¹Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Correspondence: Xia-wei Wei,(xiaweiwei@scu.edu.cn)

Adjuvants play essential roles in vaccination by enhancing and/or shaping antigen-specific immune responses1. They are commonly used in every type of vaccines, e.g., cancer vaccines, which have been proved to be a promising approach for cancer immune therapy2. Aluminum-based adjuvants have been widely used in human vaccination for decades3. Despite the robust induction of antibody-mediated immune responses, a limitation of aluminum-based adjuvants is their weak stimulation of cell-mediated immunity4. Thus, the development of safe, stable and effective adjuvants with the ability to enhance both humoral and cellular immune responses during clinical vaccination remains challenging. As the major antigen-presenting cells (APCs) to initiate immune responses, dendritic cells (DCs) can be triggered by environmental stimulation to elicit different phenotypes and functions5,6.

10.1038/cr.2017.14

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