Volume 27, No 5, May 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 5, May 2017: 600-601

RESEARCH HIGHLIGHTS

Moving towards totipotency without a single miR-acle

Noam Maoz¹ and Yosef Buganim¹

¹Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel Correspondence: Yosef Buganim,(yossibug@ekmd.huji.ac.il)

Totipotency is the ability of a single cell to form an entire embryo, including extra-embryonic tissues, an ability we have yet to recapitalize, in vitro. In a recent paper published in Science, Choi et al. showed that pluripotent stem cells lacking microRNA miR-34a, have an expanded cell fate potential allowing differentiation into not only embryonic but also extraembryonic lineages.

10.1038/cr.2017.30

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