Volume 27, No 6, Jun 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 6, June 2017: 720-721

RESEARCH HIGHLIGHTS

Spontaneous DNA damage propels tumorigenicity

Ilio Vitale^1,2 and Guido Kroemer^{3,4,5,6,7,8,9}

¹Department of Biology, University of Rome “Tor Vergata”, Rome 00133, Italy
²Regina Elena National Cancer Institute, Rome 00144, Italy
³Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris 75006, France
⁴Université Pierre et Marie Curie/Paris VI, Paris 75006, France
⁵Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris 75006, France
⁶INSERM, U1138, Paris 75006, France
⁷Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif 94805, France
⁸Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris 75015, France
⁹Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm 17176, Sweden Correspondence: Ilio Vitale, E-mail: iliovit@gmail.com; Guido Kroemer,(kroemer@orange.fr)

High levels of endogenously generated DNA damage drive oncogenesis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additional insights into this topic by uncovering a novel intrinsic source of double-strand breaks that fosters the aggressiveness and stemness of malignant cells.

10.1038/cr.2017.43

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