Volume 27, No 6, Jun 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 6, June 2017: 717-719

RESEARCH HIGHLIGHTS

5-methylcytosine mediates nuclear export of mRNA

Dan Dominissini^1,2 and Gideon Rechavi^1,2

¹Cancer Research Center and the Wohl Institute for Translational Medicine, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel;
²Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel Correspondence: Gideon Rechavi,(gidi.rechavi@sheba.health.gov.il)

5-methylcytosine was shown before to be an epitranscriptomic mark. Yang et al. now explored the unique topology of this mRNA modification, identified its writer and demonstrated its involvement in nuclear-cytoplasmic shuttling mediated by a specific reader.

10.1038/cr.2017.73

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