Volume 27, No 6, Jun 2017
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 27 Issue 6, June 2017: 722-723
RESEARCH HIGHLIGHTS
An evolving function of DNA-containing exosomes in chemotherapy-induced immune response
Paul Kurywchak1 and Raghu Kalluri1
1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77005, USA
Correspondence: Raghu Kalluri, E-mail: (rkalluri@mdanderson.org)
Chemotherapy is a predominant strategy to treat cancer and is often associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et al. recently explored the immune-mediated mechanisms of Irinotecan-induced diarrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2.
10.1038/cr.2017.74
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