Volume 27, No 7, Jul 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 7, July 2017: 851-852

RESEARCH HIGHLIGHTS

Beyond growth signaling: Paneth cells metabolically support ISCs

Talya L Dayton¹ and Hans Clevers¹

¹Hubrecht Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands Correspondence: Hans Clevers, E-mail: (h.clevers@hubrecht.eu)

Single Lgr5+ intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or “mini-guts”, self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.

10.1038/cr.2017.59

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