Volume 27, No 9, Sep 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 9, September 2017: 1075-1076

RESEARCH HIGHLIGHTS

SMAD5 signaling: more than meets the nuclei

John Orlowski¹

¹Department of Physiology, McGill Univesity, Bellini Life Sciences Bldg., Rm 166, 3649 Promenade Sir-William-Osler, Montreal, Quebec H3G 0B1, Canada Correspondence: John Orlowski, Tel: +1-514-398-8335(john.orlowski@mcgill.ca)

SMADs are essential transcriptional effectors of transforming growth factor-β (TGFβ)/TGFβ-related signaling that underlies embryonic development and adult homeostasis. A recent study by Fang et al. in Cell Research adds to this biological complexity by demonstrating an atypical cytoplasmic role for SMAD5 in modulating the bioenergetic homeostasis (i.e., glycolysis and mitochondrial respiration) of cells in response to fluctuations in intracellular pH that is independent of receptor signaling.

10.1038/cr.2017.101

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