Volume 27, No 9, Sep 2017
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 27 Issue 9, September 2017: 1079-1080
RESEARCH HIGHLIGHTS
Threading an elephant through the eye of a needle: Where are platelets made?
Ian Johnston1, Vincent Hayes2 and Mortimer Poncz3,4
1Department of Pharmacology
2Department of Pathology
3Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
4Division of Pediatrics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
Correspondence: Mortimer Poncz, Tel: +1-610-888-7442(poncz@email.chop.edu)
There has been a long-standing controversy of whether megakaryocytes release platelets in the marrow or travel to the lungs and release platelets there. Using two-photon electron microscopy and orthotopic lung transplantation, Lefrançais et al. now document that platelet release occurs physiologically in the lungs of mice from extrapulmonary megakaryocytes and that this release accounts for ~50% of total platelet production.
10.1038/cr.2017.65
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