Volume 27, No 9, Sep 2017
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 27 Issue 9, September 2017: 1178-1181
LETTERS TO THE EDITOR
Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding
Jiping Yang1,2,4,*, Jingyi Li1,3,8,9,*, Keiichiro Suzuki5,*, Xiaomeng Liu3,9, Jun Wu5,6, Weiqi Zhang1,2,8, Ruotong Ren1,2,8, Weizhou Zhang7, Piu Chan8,11, Juan Carlos Izpisua Belmonte5, Jing Qu2,4, Fuchou Tang3,9,10 and Guang-Hui Liu1,4,8,11
1National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
3Beijing Advanced Innovation Center for Genomics (ICG), Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking University, Beijing 100871, China
4University of Chinese Academy of Sciences, Beijing 100049, China
5Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
6Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, N 135 Guadalupe 30107 Murcia, Spain
7Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
8National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University
9Biomedical Institute for Pioneering Investigation via Convergence, Peking University, Beijing 100871, China
10Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
11Beijing Institute for Brain Disorders, Beijing 100069, China
Correspondence: Guang-Hui Liu, E-mail: ghliu@ibp.ac.cn; Fuchou Tang, E-mail: tangfuchou@pku.edu.cn; Jing Qu,:(qujing@ioz.ac.cn)
Cell replacement therapy holds great therapeutic promise towards restoring tissue homeostasis. However, aging-associated functional decay and neoplastic transformation following transplantation must be overcome before cell therapies can be effectively and safely implemented in the clinical settings1,2,3,4. This goal can theoretically be achieved by developing enhancement strategies towards endowing stem cells with more robust regenerative capacities and concomitantly, a reduced risk for tumorigenesis5,6.
10.1038/cr.2017.86
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