Volume 27, No 9, Sep 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 9, September 2017: 1081-1082

RESEARCH HIGHLIGHTS

RIPped for neuroinflammation

Bart Tummers¹ and Douglas R Green¹

¹Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA Correspondence: Douglas R Green,(douglas.green@stjude.org)

Activation of the receptor interacting serine/threonine kinase (RIPK) 3 mediates an inflammatory type of cell death called necroptosis; in addition, RIPK3 has necroptosis-independent roles in inflammation, although these are not well defined. In a recent study published in Cell, Daniels and colleagues demonstrate that RIPK3 controls West Nile virus infection by promoting neuroinflammation in the central nervous system without affecting neuronal death.

10.1038/cr.2017.75

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