Volume 27, No 10, Oct 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 10, October 2017: 1187-1188

RESEARCH HIGHLIGHTS

Size matters: Finding growth pathways that protect the heart

J Sawalla Guseh¹ and Anthony Rosenzweig¹

¹Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115 Correspondence: Anthony Rosenzweig, E-mail:(rosenzwe@helix.mgh.harvard.edu)

In a recent paper published in Cell Research, Abdul-Ghani and colleagues show that the cytokine, cardiotrophin-1 (CT1), drives a protective form of reversible cardiac hypertrophy that acts through a nonapoptotic caspase-dependent mechanism. Since CT1 can be delivered as exogenous protein, these studies provide new biological insights and potential translational opportunities.

10.1038/cr.2017.120

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