Volume 27, No 10, Oct 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 10, October 2017: 1193-1194

RESEARCH HIGHLIGHTS

Coding GPCR-G protein specificity

Sebastian GB Furness¹ and Patrick M Sexton¹

¹Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 Victoria, Australia Correspondence: Sebastian GB Furness, E-mail: sebastian.furness@monash.edu; Patrick M Sexton,(patrick.sexton@monash.edu)

G protein-coupled receptors (GPCRs) are ubiquitous gatekeepers of cellular response and signal predominantly by recruitment and activation of G proteins. In a recent paper in Nature, Flock et al. use large-scale bioinformatics to build a model of GPCR-G protein selectivity and an interactive database to interrogate potential receptor-G protein interactions.

10.1038/cr.2017.92

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