Volume 27, No 11, Nov 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 11, November 2017: 1302-1303

RESEARCH HIGHLIGHTS

NLRP9b: a novel RNA-sensing inflammasome complex

Chinh Ngo¹ and Si Ming Man¹

¹Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Canberra, 2601, Australia Correspondence: Si Ming Man, Tel: 61 612 56793(siming.man@anu.edu.au)

Inflammasome sensors recognize pathogens and danger signals and assemble an immune signaling complex, which induces the secretion of pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. A new study published in Nature now describes a new inflammasome sensor NLRP9b in intestinal epithelial cells, which in concert with the RNA sensor DHX9, recognize short dsRNA from Rotavirus.

10.1038/cr.2017.93

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