Volume 27, No 11, Nov 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 11, November 2017: 1304-1306

RESEARCH HIGHLIGHTS

Structural step forward for NHEJ

Go Watanabe¹, Michael R Lieber¹ and Dewight Williams²

¹USC Norris Comprehensive Cancer Ctr., 1441 Eastlake Ave., Los Angeles, CA 90089-9176, USA;
²LeRoy Eyring Center for Solid State Science, Physical Sciences Bldg A-213, 901 S. Palm Walk, Tempe, AZ 85287-1704, USA Correspondence: Michael R Lieber,(lieber@usc.edu)

In a recent paper published in Cell Research, a cryo-EM structure reveals the interface between DNA-PKcs and the Ku70/80:DNA complex, together forming the DNA-dependent protein kinase holoenzyme in non-homologous DNA end joining. Insight from this structure suggests how an allosteric rearrangement of DNA-PKcs driven by Ku70/80:DNA binding regulates kinase activity in this largest member of a family of structurally homologous phosphoinositide 3-kinase-related protein kinases that includes mTOR, ATR, and ATM.

10.1038/cr.2017.119

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