Volume 27, No 11, Nov 2017

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 27 Issue 11, November 2017: 1397-1400   |  Open Access

LETTERS TO THE EDITOR

Pairing of integrins with ECM proteins determines migrasome formation

Danni Wu¹, Yue Xu², Tianlun Ding¹, Yan Zu², Chun Yang² and Li Yu1

¹State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Science, Beijing 100084, China
²Institute of Biomechanics and Medical Engineering, School of Aerospace, Tsinghua University, Beijing 100084, China. Correspondence: Li Yu, E-mail: liyulab@mail.tsinghua.edu.cn; Chun Yang,(yangchun@mail.tsinghua.edu.cn)

Recently we reported the discovery of migrasome, a new organelle of migrating cells1. Migrasomes are large vesicles that grow on the tips or intersections of retraction fibers at the rear of migrating cells. Following cell migration, the retraction fibers eventually break and the migrasomes become detached. The migrasomes and their contents, including cytosolic components and vesicles of unknown origin, are released into the extracellular space —— a process we named as migracytosis. We speculated that migracytosis may play important roles in cell-cell communication.

10.1038/cr.2017.108

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