Volume 27, No 12, Dec 2017
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 27 Issue 12, December 2017: 1403-1404
RESEARCH HIGHLIGHTS
Hunting for the mutant without the MAP(K)
Leon Tejwani1,2,3, Janghoo Lim1,2,3,4
1Yale University, Interdepartmental Neuroscience Program, 295 Congress Avenue BCMM454C, New Haven, CT 06510, USA;
2 Yale University School of Medicine, Department of Neuroscience, New Haven, CT 06510, USA;
3 Yale University School of Medicine, Program in Cellular Neuroscience, Neurodegeneration and Repair, New Haven, CT 06510, USA;
4 Yale University School of Medicine, Department of Genetics, New Haven, CT 06510, USA
Correspondence: Janghoo Lim(janghoo.lim@yale.edu)
In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington’s disease (HD) pathology. The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.
10.1038/cr.2017.140
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