Volume 27, No 12, Dec 2017
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 27 Issue 12, December 2017: 1405-1406
RESEARCH HIGHLIGHTS
TDP2, TOP2, and SUMO: what is ZATT about?
Guido Zagnoli-Vieira1, Keith W Caldecott
1Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom
Correspondence: Keith W Caldecotta,E-mail: k.w.caldecott@sussex.ac.uk; Guido Zagnoli-Vieirab,(G.Zagnoli-Vieira@sussex.ac.uk)
Recently, ZATT (also known as ZNF451 or Zpf451) was reported by Schellenberg et al. to aid the removal of Topoisomerase II cleavage complexes by stimulating the phosphodiesterase activity of Tyrosyl DNA Phosphodiesterase 2. Although the full implication of this discovery is unknown, it will help us understand how cells respond to topoisomerase-induced genome damage and chemotherapeutic topoisomerase 'poisons'.
10.1038/cr.2017.147
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