Volume 28, No 1, Jan 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 1, January 2018: 5-6

RESEARCH HIGHLIGHTS

Portending death in germinal centers — when B cells know their time is up

Lili Wang¹, Markus Müschen¹

¹Department of Systems Biology, Beckman Research Institute and NCI City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA Correspondence: Markus Müschen(mmuschen@coh.org)

B cells undergo stringent selection in germinal centers (GCs) for expression of high-affinity antibodies, however, mechanisms of negative selection of low-affinity B cell clones remain elusive. A new study by Michel Nussenzweig's group published in Science leverages a new reporter system that marks pre-apoptotic GC B cells to dissect microanatomic regions of GCs and their role in affinity maturation.

10.1038/cr.2017.151

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