Volume 28, No 1, Jan 2018
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 28 Issue 1, January 2018: 7-8
RESEARCH HIGHLIGHTS
TRFH domain: at the root of telomere protein evolution?
Marie-Joseph Giraud-Panis1, Jing Ye2, Eric Gilson1, 2, 3
1 Université Côte d’Azur, CNRS UMR7284; Inserm U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice 06107, France;
2 International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital/CNRS/Inserm/Nice University, Pôle Sino-Français de Recherche en Sciences du Vivant et Génomique, Shanghai, China;
3 Department of Medical Genetics, Archet 2 hospital, CHU of Nice, Nice, France
Correspondence: Eric Gilson(Eric.GILSON@unice.fr)
Two articles in Cell Research focus on the structure-function relationships in the shelterin complex that binds to telomeres and is essential for their stability and functions. These studies concerning both mammalian and Schizosaccharomyces pombe proteins reveal unexpected structural conservation of a motif called TRFH (Telomeric Repeat Factors Homology) domain between several subunits in these complexes, providing a rationale for further dissection of the role of telomeres in chromosome stability, aging and cancer, and encouraging us to revisit the evolution of telomere proteins.
10.1038/cr.2017.152
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