Volume 28, No 1, Jan 2018
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 28 Issue 1, January 2018: 3-4
RESEARCH HIGHLIGHTS
PRRT2-dependent dyskinesia: cerebellar, paroxysmal and persisten
Lieke Kros1, Chris I De Zeeuw1,2
1Department of Neuroscience, Erasmus MC Rotterdam, the Netherlands;
2Netherlands Institute for Neuroscience, Royal Dutch Academy for Arts and Sciences, Amsterdam, the Netherlands
Correspondence: Chris I De Zeeuw(c.dezeeuw@erasmusmc.nl)
In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity patterns of Purkinje cells, the sole output of the cerebellar cortex.
10.1038/cr.2017.142
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