Volume 28, No 2, Feb 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 2, February 2018: 137-138

RESEARCH HIGHLIGHTS

GOTcha: lncRNA-ACOD1 targets metabolism during viral infection

Marah C Runtsch¹, Luke AJ O’Neill¹

¹School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Correspondence: Marah C Runtscha, Luke AJ O’Neillb Tel: 353-18962449 E-mail: runtschm@tcd.ie(LAONEILL@tcd.ie)

Long-noncoding RNAs (lncRNAs) are emerging as important regulators of cellular processes, but few have been functionally characterized in host-pathogen interactions. A recent report in Science demonstrates a mechanistic role for a novel lncRNA in directly binding an essential metabolic enzyme, glutamic-oxaloacetic transaminase (GOT2); this interaction benefits viral replication via alteration of host metabolism.

10.1038/cr.2017.153

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